Causes of female infertility Female infertility can be caused by a variety of factors that affect or interfere with the following biological processes: ovulation, when the mature egg is released from the ovary fertilization, which occurs when sperm meets the egg in the fallopian tube after traveling through the cervix and uterus implantation, which occurs when a fertilized egg attaches to the lining of the uterus where it can then grow and develop into a baby Risk factors Risk factors for female infertility include: increasing age smoking cigarettes heavy use of alcohol being overweight, obese, or significantly underweight having certain sexually transmitted infections (STIs) that can damage the reproductive system Medical conditions A variety of medical conditions can affect the female reproductive system and cause infertility in women. Examples include: ovulation disorders, which can be caused by polycystic ovary syndrome (PCOS) or hormonal imbalances pelvic inflammatory disease (PID) endometriosis uterine fibroids premature ovarian failure scarring from a previous surgery Medications and drugs Certain medications and drugs that can affect female infertility include: chemotherapy or radiation therapy long-term use of high-dosage nonsteroidal anti-inflammatory drugs (NSAIDS) such as aspirin (Bayer) and ibuprofen (Advil, Motrin) antipsychotic medications recreational drugs such as marijuana and cocaine Ashwini Hospital & fertility Centre Moondrumavadi K.Pudur Madurai-07 , Best Fertility Care Centre , Maternal & Child Health Care Centre , Advanced Fertility Care Centre .